H2N2V1, Main, Exploration, bibRecord, 001A69

Enhanced immune responses and resistance against infection in aged mice conferred by Flu-ISCOMs vaccine correlate with up-regulation of costimulatory molecule CD86

Identifieur interne : 001A69 ( Main/Exploration ); précédent : 001A68; suivant : 001A70

Enhanced immune responses and resistance against infection in aged mice conferred by Flu-ISCOMs vaccine correlate with up-regulation of costimulatory molecule CD86

Auteurs : Suryaprakash Sambhara [Canada] ; Anjna Kurichh [Canada] ; Renata Miranda [Canada] ; Alan Tamane [Canada] ; Rita Arpino [Canada] ; Olive James [Canada] ; Ursula Mcguinness [Canada] ; Ali Kandil [Canada] ; Brian Underdown [Canada] ; Michel Klein [Canada] ; David Burt [Canada]

Source :

Vaccine [ 0264-410X ] ; 1998.

RBID : ISTEX:41AE7CADEF7EF49F329B1DE85FC5788E2E0035D0

English descriptors

Teeft :
- Alternate days, Antibody titres, Antigen processing, Apc, Background expression, Better protection, Cell activation, Dysfunction, Elisa, Elisa titres, Elsevier science, Flow cytometric analysis, Flow cytometry, Functional readout, Goat antimouse, Higher affinity, Higher levels, Homotypic virus, Immune, Immune dysfunction, Immune response, Immune responses, Immune system, Immunization, Individual mice, Influenza, Influenza antigens, Influenza vaccine, Influenza virus, Influenza virus infection, Influenza virus vaccine, Influenza viruses, Intranasal route, Iscoms, Lesser extent, Lethal challenge, Lymphocyte, Monoclonal antibodies, Mouse, Paramount importance, Present study, Presentation function, Room temperature, Sambhara, Sera samples, Spleen, Spleen cells, Splenic, Splenic apcs, Titre, Vaccine, Virus, Virus challenge, Weight changes, Weight loss, Young mice.

Abstract

Abstract: Ageing is associated with a decline in immune function and our primary objective is to ‘reverse’ age-related decline in protective immune responses to vaccination by formulating vaccines in appropriate delivery systems. In this paper, we demonstrate that influenza vaccine formulated as ISCOMs is highly immunogenic and confers protection in aged mice, when compared to current influenza vaccine. The enhanced protection conferred by Flu-ISCOMs in aged mice correlates with the up-regulation of co-stimulatory molecule, CD86 (B7.2) and to a lesser extent, CD80 (B7.1) expression on antigen presenting cells.

Url:

https://api.istex.fr/ark:/67375/6H6-Z8H54G9N-B/fulltext.pdf

DOI: 10.1016/S0264-410X(98)00130-3

Affiliations:

Canada

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Ageing is associated with a decline in immune function and our primary objective is to ‘reverse’ age-related decline in protective immune responses to vaccination by formulating vaccines in appropriate delivery systems. In this paper, we demonstrate that influenza vaccine formulated as ISCOMs is highly immunogenic and confers protection in aged mice, when compared to current influenza vaccine. The enhanced protection conferred by Flu-ISCOMs in aged mice correlates with the up-regulation of co-stimulatory molecule, CD86 (B7.2) and to a lesser extent, CD80 (B7.1) expression on antigen presenting cells.</div>
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Enhanced immune responses and resistance against infection in aged mice conferred by Flu-ISCOMs vaccine correlate with up-regulation of costimulatory molecule CD86

Enhanced immune responses and resistance against infection in aged mice conferred by Flu-ISCOMs vaccine correlate with up-regulation of costimulatory molecule CD86

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri